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The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression
Joint Authors
Crisucci, Elia M.
Arndt, Karen M.
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The conserved Paf1 complex (Paf1C) carries out multiple functions during transcription by RNA polymerase (pol) II, and these functions are required for the proper expression of numerous genes in yeast and metazoans.
In the elongation stage of the transcription cycle, the Paf1C associates with RNA pol II, interacts with other transcription elongation factors, and facilitates modifications to the chromatin template.
At the end of elongation, the Paf1C plays an important role in the termination of RNA pol II transcripts and the recruitment of proteins required for proper RNA 3′ end formation.
Significantly, defects in the Paf1C are associated with several human diseases.
In this paper, we summarize current knowledge on the roles of the Paf1C in RNA pol II transcription.
American Psychological Association (APA)
Crisucci, Elia M.& Arndt, Karen M.. 2011. The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genetics Research International،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-492199
Modern Language Association (MLA)
Crisucci, Elia M.& Arndt, Karen M.. The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genetics Research International No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-492199
American Medical Association (AMA)
Crisucci, Elia M.& Arndt, Karen M.. The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-492199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492199