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Obesity and the Ageing Brain : Could Leptin Play a Role in Neurodegeneration?
Author
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity and ageing are both characteristics of the human population that are on the increase across the globe.
It has long been established that ageing is the major risk factor for neurodegenerative conditions such as Alzheimer's disease, and it is becoming increasingly evident that obesity is another such factor.
Leptin resistance or insensitivity has been uncovered as a cause of obesity, and in addition the leptin signalling system is less potent in the elderly.
Taken together, these findings reveal that this molecule may be a link between neurodegeneration and obesity or ageing.
It is now known that leptin has beneficial effects on both the survival and neurophysiology of the neurons that are lost in Alzheimer's disease suggesting that it may be an important research target in the quest for strategies to prevent, halt, or cure this condition.
American Psychological Association (APA)
Doherty, G. H.. 2011. Obesity and the Ageing Brain : Could Leptin Play a Role in Neurodegeneration?. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492224
Modern Language Association (MLA)
Doherty, G. H.. Obesity and the Ageing Brain : Could Leptin Play a Role in Neurodegeneration?. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-492224
American Medical Association (AMA)
Doherty, G. H.. Obesity and the Ageing Brain : Could Leptin Play a Role in Neurodegeneration?. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492224