Perisynaptic GABA Receptors : The Overzealous Protector
Author
Source
Advances in Pharmacological Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An attempt to find pharmacological therapies to treat stroke patients and minimize the extent of cell death has seen the failure of dozens of clinical trials.
As a result, stroke/cerebral ischemia is the leading cause of lasting adult disability.
Stroke-induced cell death occurs due to an excess release of glutamate.
As a consequence to this, a compensatory increased release of GABA occurs that results in the subsequent internalization of synaptic GABAA receptors and spillover onto perisynaptic GABAA receptors, resulting in increased tonic inhibition.
Recent studies show that the brain can engage in a limited process of neural repair after stroke.
Changes in cortical sensory and motor maps and alterations in axonal structure are dependent on patterned neuronal activity.
It has been assumed that changes in neuronal excitability underlie processes of neural repair and remapping of cortical sensory and motor representations.
Indeed, recent evidence suggests that local inhibitory and excitatory currents are altered after stroke and modulation of these networks to enhance excitability during the repair phase can facilitate functional recovery after stroke.
More specifically, dampening tonic GABA inhibition can afford an early and robust improvement in functional recovery after stroke.
American Psychological Association (APA)
Clarkson, Andrew N.. 2012. Perisynaptic GABA Receptors : The Overzealous Protector. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492255
Modern Language Association (MLA)
Clarkson, Andrew N.. Perisynaptic GABA Receptors : The Overzealous Protector. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492255
American Medical Association (AMA)
Clarkson, Andrew N.. Perisynaptic GABA Receptors : The Overzealous Protector. Advances in Pharmacological Sciences. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492255