Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders
Joint Authors
Bossolasco, Simona
Picchi, Giovanna
Bini, Teresa
Baldini, Francesco
Lorenzini, Patrizia
Monno, Laura
Cinque, Paola
Giancola, Maria Letizia
d’Arminio Monforte, Antonella
Cingolani, Antonella
Antinori, Andrea
Tozzi, Valerio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to analyse the effect of antiretroviral (ARV) therapy and single antiretroviral drugs on cerebrospinal fluid (CSF) HIV-RNA burden in HIV-infected patients affected by neurological disorders enrolled in a multicentric Italian cohort.
ARVs were considered “neuroactive” from literature reports.
Three hundred sixty-three HIV-positive patients with available data from paired plasma and CSF samples, were selected.
One hundred twenty patients (33.1%) were taking ARVs at diagnosis of neurological disorder.
Mean CSF HIV-RNA was significantly higher in naïve than in experienced patients, and in patients not taking ARV than in those on ARV.
A linear correlation between CSF HIV-RNA levels and number of neuroactive drugs included in the regimen was also found (r=−0.44, P<0.001).
Low -plasma HIV-RNA and the lack of neurocognitive impairment resulted in independently associated to undetectable HIV-RNA.
Taking nevirapine or efavirenz, or regimen including NNRTI, NNRTI plus PI or boosted PI, was independently associated to an increased probability to have undetectable HIV-RNA in CSF.
The inclusion of two or three neuroactive drugs in the ARV regimen was independently associated to undetectable viral load in CSF.
Our data could be helpful in identifying ARV regimens able to better control HIV replication in the CNS sanctuary, and could be a historical reference for further analyses.
American Psychological Association (APA)
Giancola, Maria Letizia& Lorenzini, Patrizia& Cingolani, Antonella& Baldini, Francesco& Bossolasco, Simona& Bini, Teresa…[et al.]. 2012. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492259
Modern Language Association (MLA)
Giancola, Maria Letizia…[et al.]. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-492259
American Medical Association (AMA)
Giancola, Maria Letizia& Lorenzini, Patrizia& Cingolani, Antonella& Baldini, Francesco& Bossolasco, Simona& Bini, Teresa…[et al.]. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492259