Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders

Joint Authors

Bossolasco, Simona
Picchi, Giovanna
Bini, Teresa
Baldini, Francesco
Lorenzini, Patrizia
Monno, Laura
Cinque, Paola
Giancola, Maria Letizia
d’Arminio Monforte, Antonella
Cingolani, Antonella
Antinori, Andrea
Tozzi, Valerio

Source

AIDS Research and Treatment

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-08-26

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

The aim of the present study was to analyse the effect of antiretroviral (ARV) therapy and single antiretroviral drugs on cerebrospinal fluid (CSF) HIV-RNA burden in HIV-infected patients affected by neurological disorders enrolled in a multicentric Italian cohort.

ARVs were considered “neuroactive” from literature reports.

Three hundred sixty-three HIV-positive patients with available data from paired plasma and CSF samples, were selected.

One hundred twenty patients (33.1%) were taking ARVs at diagnosis of neurological disorder.

Mean CSF HIV-RNA was significantly higher in naïve than in experienced patients, and in patients not taking ARV than in those on ARV.

A linear correlation between CSF HIV-RNA levels and number of neuroactive drugs included in the regimen was also found (r=−0.44, P<0.001).

Low -plasma HIV-RNA and the lack of neurocognitive impairment resulted in independently associated to undetectable HIV-RNA.

Taking nevirapine or efavirenz, or regimen including NNRTI, NNRTI plus PI or boosted PI, was independently associated to an increased probability to have undetectable HIV-RNA in CSF.

The inclusion of two or three neuroactive drugs in the ARV regimen was independently associated to undetectable viral load in CSF.

Our data could be helpful in identifying ARV regimens able to better control HIV replication in the CNS sanctuary, and could be a historical reference for further analyses.

American Psychological Association (APA)

Giancola, Maria Letizia& Lorenzini, Patrizia& Cingolani, Antonella& Baldini, Francesco& Bossolasco, Simona& Bini, Teresa…[et al.]. 2012. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492259

Modern Language Association (MLA)

Giancola, Maria Letizia…[et al.]. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-492259

American Medical Association (AMA)

Giancola, Maria Letizia& Lorenzini, Patrizia& Cingolani, Antonella& Baldini, Francesco& Bossolasco, Simona& Bini, Teresa…[et al.]. Virological Response in Cerebrospinal Fluid to Antiretroviral Therapy in a Large Italian Cohort of HIV-Infected Patients with Neurological Disorders. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-492259

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492259