Comparison of Two Mice Strains, AJ and C57BL6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection
Joint Authors
Kim, Se Kon
Chae, Gue Tae
Jin, Song Hou
Kang, Tae Jin
Lee, Geum Seon
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A/J mice were found to have amino acid differences in Naip5, one of the NOD-like receptors (NLRs) involved in the cytosolic recognition of pathogen-associated molecular patterns and one of the adaptor proteins for caspase-1 activation.
This defect was associated with a susceptibility to Legionella infection, suggesting an important role for Naip5 in the immune response also to other intracellular pathogens, such as Mycobacterium leprae.
In this study, the immune responses of macrophages from A/J mice against M.
leprae were compared to those of macrophages from C57BL/6 mice.
Infection with M.
leprae induced high levels of TNF-α production and NF-κB activation in A/J and C57BL/6 macrophages.
Caspase-1 activation and IL-1β secretion were also induced in both macrophages.
However, macrophages from A/J mice exhibited reduced caspase-1 activation and IL-1β secretion compared to C57BL/6 macrophages.
These results suggest that NLR family proteins may have a role in the innate immune response to M.
leprae.
American Psychological Association (APA)
Kang, Tae Jin& Lee, Geum Seon& Kim, Se Kon& Jin, Song Hou& Chae, Gue Tae. 2010. Comparison of Two Mice Strains, AJ and C57BL6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-492287
Modern Language Association (MLA)
Kang, Tae Jin…[et al.]. Comparison of Two Mice Strains, AJ and C57BL6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection. Mediators of Inflammation No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-492287
American Medical Association (AMA)
Kang, Tae Jin& Lee, Geum Seon& Kim, Se Kon& Jin, Song Hou& Chae, Gue Tae. Comparison of Two Mice Strains, AJ and C57BL6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-492287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492287