Multiple Sclerosis : Are Protective Immune Mechanisms Compromised by a Complex Infectious Background?
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The immunological background of multiple sclerosis (MS) manifests as an altered reactivity against a diverse range of infections, particularly with the Epstein-Barr virus.
Although this could be only an epiphenomenon of a more generalised dysfunction of the immune system in MS, it is also possible that a complex infectious background forms the basis of a specific immune dysregulation finally causing the disease.
It is thus suggested that the complex infectious background bears the key for an understanding of the immune pathogenesis of the disease.
It appears probable that improved standards of hygiene cause regulatory defects in the immune system, allowing the abnormal expression of human endogenous retroviral (HERV) genes.
On the basis of epidemiological observations we describe how a failure of expansion or an eclipse of a subfraction of self-antigen-specific CD8+ T cells mediating immune repair, and a deleterious mode of action of HERV gene products, could underlie the pathogenesis of MS.
American Psychological Association (APA)
Krone, Bernd& Grange, John M.. 2010. Multiple Sclerosis : Are Protective Immune Mechanisms Compromised by a Complex Infectious Background?. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492290
Modern Language Association (MLA)
Krone, Bernd& Grange, John M.. Multiple Sclerosis : Are Protective Immune Mechanisms Compromised by a Complex Infectious Background?. Autoimmune Diseases No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-492290
American Medical Association (AMA)
Krone, Bernd& Grange, John M.. Multiple Sclerosis : Are Protective Immune Mechanisms Compromised by a Complex Infectious Background?. Autoimmune Diseases. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492290