May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?
Joint Authors
Siciliano, Gabriele
Ienco, Elena Caldarazzo
Filosto, Massimiliano
Mancuso, Michelangelo
Orsucci, Daniele
Simoncini, Costanza
Petrucci, Loredana
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways.
Multiple evidences suggest that mitochondria may be crucial in ageing-related neurodegenerative diseases.
Moreover, mitochondrial haplogroups have been linked to multiple area of medicine, from normal ageing to diseases, including neurodegeneration.
Polymorphisms within the mitochondrial genome might lead to impaired energy generation and to increased amount of reactive oxygen species, having either susceptibility or protective role in several diseases.
Here, we highlight the role of the mitochondrial haplogroups in the pathogenetic cascade leading to diseases, with special attention to Alzheimer's disease.
American Psychological Association (APA)
Ienco, Elena Caldarazzo& Simoncini, Costanza& Orsucci, Daniele& Petrucci, Loredana& Filosto, Massimiliano& Mancuso, Michelangelo…[et al.]. 2011. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492315
Modern Language Association (MLA)
Ienco, Elena Caldarazzo…[et al.]. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-492315
American Medical Association (AMA)
Ienco, Elena Caldarazzo& Simoncini, Costanza& Orsucci, Daniele& Petrucci, Loredana& Filosto, Massimiliano& Mancuso, Michelangelo…[et al.]. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492315