May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?

Joint Authors

Siciliano, Gabriele
Ienco, Elena Caldarazzo
Filosto, Massimiliano
Mancuso, Michelangelo
Orsucci, Daniele
Simoncini, Costanza
Petrucci, Loredana

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-02-22

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases
Medicine

Abstract EN

Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways.

Multiple evidences suggest that mitochondria may be crucial in ageing-related neurodegenerative diseases.

Moreover, mitochondrial haplogroups have been linked to multiple area of medicine, from normal ageing to diseases, including neurodegeneration.

Polymorphisms within the mitochondrial genome might lead to impaired energy generation and to increased amount of reactive oxygen species, having either susceptibility or protective role in several diseases.

Here, we highlight the role of the mitochondrial haplogroups in the pathogenetic cascade leading to diseases, with special attention to Alzheimer's disease.

American Psychological Association (APA)

Ienco, Elena Caldarazzo& Simoncini, Costanza& Orsucci, Daniele& Petrucci, Loredana& Filosto, Massimiliano& Mancuso, Michelangelo…[et al.]. 2011. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492315

Modern Language Association (MLA)

Ienco, Elena Caldarazzo…[et al.]. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-492315

American Medical Association (AMA)

Ienco, Elena Caldarazzo& Simoncini, Costanza& Orsucci, Daniele& Petrucci, Loredana& Filosto, Massimiliano& Mancuso, Michelangelo…[et al.]. May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492315

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492315