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Investigations of Curcumin and Resveratrol on Neurite Outgrowth : Perspectives on Spinal Muscular Atrophy
Joint Authors
Erdem-Yurter, Hayat
Bora-Tatar, Gamze
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Spinal Muscular Atrophy (SMA) is an autosomal recessive neurodegenerative disease with progressive muscle weakness and atrophy.
SMA is caused by low levels of the Survival of Motor Neuron (SMN) protein, which also leads to neurite outgrowth defects in neuronal cells.
Rescue of the outgrowth defect is thought to be a strategy for SMA treatment.
Polyphenolic histone deacetylase (HDAC) inhibitors might be good candidates due to their neuritogenic properties.
In the present study, it was investigated whether neurite outgrowth defects could be rescued by curcumin and resveratrol, which are SMN-inducing polyphenols, having HDAC inhibition activity.
According to our results, although curcumin and resveratrol failed to restore the neurite outgrowth defects, the SMN protein was found to be necessary for the neurite-promoting activity of curcumin in neuron-like PC12 cells.
American Psychological Association (APA)
Bora-Tatar, Gamze& Erdem-Yurter, Hayat. 2014. Investigations of Curcumin and Resveratrol on Neurite Outgrowth : Perspectives on Spinal Muscular Atrophy. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492320
Modern Language Association (MLA)
Bora-Tatar, Gamze& Erdem-Yurter, Hayat. Investigations of Curcumin and Resveratrol on Neurite Outgrowth : Perspectives on Spinal Muscular Atrophy. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-492320
American Medical Association (AMA)
Bora-Tatar, Gamze& Erdem-Yurter, Hayat. Investigations of Curcumin and Resveratrol on Neurite Outgrowth : Perspectives on Spinal Muscular Atrophy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492320