Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice
Joint Authors
Park, Kwang-Kyun
Yoon Park, Jung Han
Choi, Jong-Hoon
Chung, Won-Yoon
Jeong, Chan-Kwon
Kim, Ki Rim
Lim, Soon Sung
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The anti-inflammatory activity of licorice (LE) and roated licorice (rLE) extracts determined in the murine phorbol ester-induced acute inflammation model and collagen-induced arthritis (CIA) model of human rheumatoid arthritis.
rLE possessed greater activity than LE in inhibiting phorbol ester-induced ear edema.
Oral administration of LE or rLE reduced clinical arthritis score, paw swelling, and histopathological changes in a murine CIA.
LE and rLE decreased the levels of proinflammatory cytokines in serum and matrix metalloproteinase-3 expression in the joints.
Cell proliferation and cytokine secretion in response to type II collagen or lipopolysaccharide stimulation were suppressed in spleen cells from LE or rLE-treated CIA mice.
Furthermore, LE and rLE treatment prevented oxidative damages in liver and kidney tissues of CIA mice.
Taken together, LE and rLE have benefits in protecting against both acute inflammation and chronic inflammatory conditions including rheumatoid arthritis.
rLE may inhibit the acute inflammation more potently than LE.
American Psychological Association (APA)
Kim, Ki Rim& Jeong, Chan-Kwon& Park, Kwang-Kyun& Choi, Jong-Hoon& Yoon Park, Jung Han& Lim, Soon Sung…[et al.]. 2010. Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-492341
Modern Language Association (MLA)
Kim, Ki Rim…[et al.]. Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-492341
American Medical Association (AMA)
Kim, Ki Rim& Jeong, Chan-Kwon& Park, Kwang-Kyun& Choi, Jong-Hoon& Yoon Park, Jung Han& Lim, Soon Sung…[et al.]. Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-492341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492341