Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b
Joint Authors
Celis de la Rosa, A. J.
Macías-Islas, Miguel Ángel
Pacheco Moisés, Fermín Paul
Orozco-Aviña, G.
Sorto-Gomez, T. E.
Torres-Sanchez, E. D.
Ortiz, Genaro Gabriel
Ramírez-Ramírez, Viridiana
Cruz-Ramos, J. A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system.
Oxidative stress is also thought to promote tissue damage in multiple sclerosis.
Current research findings suggest that omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapenta-enoic acid (EPA) and docosahexaenoic acid (DHA) contained in fish oil may have anti-inflammatory, antioxidant, and neuroprotective effects.
The aim of the present work was to evaluate the efficacy of fish oil supplementation on serum proinflammatory cytokine levels, oxidative stress markers, and disease progression in MS.
50 patients with relapsing-remitting MS were enrolled.
The experimental group received orally 4 g/day of fish oil for 12 months.
The primary outcome was serum TNFα levels; secondary outcomes were IL-1β 1b, IL-6, nitric oxide catabolites, lipoperoxides, progression on the expanded disability status scale (EDSS), and annualized relapses rate (ARR).
Fish oil treatment decreased the serum levels of TNFα, IL-1β, IL-6, and nitric oxide metabolites compared with placebo group (P≤0.001).
There was no significant difference in serum lipoperoxide levels during the study.
No differences in EDSS and ARR were found.
Conclusion.
Fish oil supplementation is highly effective in reducing the levels of cytokines and nitric oxide catabolites in patients with relapsing-remitting MS.
American Psychological Association (APA)
Ramírez-Ramírez, Viridiana& Macías-Islas, Miguel Ángel& Ortiz, Genaro Gabriel& Pacheco Moisés, Fermín Paul& Torres-Sanchez, E. D.& Sorto-Gomez, T. E.…[et al.]. 2013. Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492354
Modern Language Association (MLA)
Ramírez-Ramírez, Viridiana…[et al.]. Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-492354
American Medical Association (AMA)
Ramírez-Ramírez, Viridiana& Macías-Islas, Miguel Ángel& Ortiz, Genaro Gabriel& Pacheco Moisés, Fermín Paul& Torres-Sanchez, E. D.& Sorto-Gomez, T. E.…[et al.]. Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492354