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The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization
Joint Authors
Kang, Cheol-In
Rouse, Mark S.
Patel, Robin
Juhn, Young J.
Zhao, Hongxia
Kita, Hirohito
Source
International Journal of Microbiology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Interleukin- (IL-) 17 is important in the development of asthma and host defense against pneumococci.
We determined the role of IL-17 in the risk of pneumococcal pneumonia.
We challenged mice intranasally with a bioluminescent Streptococcus pneumoniae strain after sensitization and challenge with ovalbumin (OVA).
We measured the levels of cytokines, including IL-17 (pg/mL), in the lung homogenate in experimental mice with and without OVA sensitization/challenge, as well as those with and without pneumococcal pneumonia.
IL-17 levels were significantly lower in OVA-sensitized/challenged mice (9.69 ± 1.49), compared to the control mice (20.92 ± 1.82, P < 0.001).
In our overall analysis, including IL-4 and IL-17 levels and OVA sensitization/challenge, IL-4 levels (OR: 81.9, 95%CI: 4.3–1523 per increment of 1.0 pg/mL, P = 0.003) were more significant than IL-17 levels (OR: 1.1, 95%CI: 1.03–1.17 per increment of 1.0 pg/mL, P = 0.003) in determining the risk of pneumococcal pneumonia.
IL-17 levels result in a much smaller impact on the risk for pneumococcal pneumonia, compared to IL-4 levels.
American Psychological Association (APA)
Zhao, Hongxia& Kang, Cheol-In& Rouse, Mark S.& Patel, Robin& Kita, Hirohito& Juhn, Young J.. 2011. The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization. International Journal of Microbiology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492358
Modern Language Association (MLA)
Zhao, Hongxia…[et al.]. The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization. International Journal of Microbiology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-492358
American Medical Association (AMA)
Zhao, Hongxia& Kang, Cheol-In& Rouse, Mark S.& Patel, Robin& Kita, Hirohito& Juhn, Young J.. The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization. International Journal of Microbiology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492358