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Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells
Joint Authors
Gupta, Smiti Vaid
Parasramka, Mansi A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic cancer (PaCa) is a major health concern due to its aggressiveness and early metastasis.
Current treatments for PaCa are limited by development of resistance against therapy.
As an alternative strategy, we assessed the combinatorial effect of dietary compounds, garcinol and curcumin, on human PaCa cells (BxPC-3 and Panc-1).
A significant (P<0.05) dose-dependent reduction in cell viability and increase in apoptosis were observed in both cell lines as compared to untreated controls.
A combination index (CI) value < 1, for a two-way comparison of curcumin and garcinol, suggests synergism.
The potency (Dm) of the combination of garcinol and curcumin was 2 to 10 fold that of the individual agents.
This indicates that curcumin and garcinol in combination exhibit a high level of synergism, with enhanced bioactivity, thereby reducing the required effective dose required for each individually.
This combinatorial strategy may hold promise in future development of therapies against PaCa.
American Psychological Association (APA)
Parasramka, Mansi A.& Gupta, Smiti Vaid. 2012. Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells. Journal of Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492381
Modern Language Association (MLA)
Parasramka, Mansi A.& Gupta, Smiti Vaid. Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells. Journal of Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492381
American Medical Association (AMA)
Parasramka, Mansi A.& Gupta, Smiti Vaid. Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492381