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Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)
Joint Authors
Lammey, M. Lon
Ely, John J.
Zavaskis, Tony
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
C-reactive protein, a conserved acute-phase protein synthesized in the liver and involved in inflammation, infection, and tissue damage, is an informative biomarker for human cardiovascular disease.
Out of 258 captive adult common chimpanzees (Pan troglodytes) assayed for CRP, 27.9% of the data were below the quantitation limit.
Data were analyzed by the Kaplan-Meier method and results compared to other methods for handling censored data (including deletion, replacement, and imputation).
Kaplan-Meier results demonstrated a modest age effect and a strong effect of HCV infection in reducing CRP but did not allow inference of reference intervals.
Results of other methods varied considerably.
Substitution schemes differed widely in statistical significance, with estimated group means biased by the size of the substitution constant, while inference of unbiased reference intervals was impossible.
Single imputation gave reasonable statistical inferences but unreliable reference intervals.
Multiple imputation gave reliable results, for both statistical inference and reference intervals, and was comparable to the Kaplan-Meier standard.
Other methods should be avoided.
CRP did not predict cardiovascular disease, but CRP levels were reduced by 50% in animals with hepatitis C infection and showed inverse relationships with 2 liver function enzymes.
Results suggested that hsCRP can be an informative biomarker of chronic hepatic dysfunction.
American Psychological Association (APA)
Ely, John J.& Zavaskis, Tony& Lammey, M. Lon. 2013. Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes). Journal of Biomarkers،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492382
Modern Language Association (MLA)
Ely, John J.…[et al.]. Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes). Journal of Biomarkers No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-492382
American Medical Association (AMA)
Ely, John J.& Zavaskis, Tony& Lammey, M. Lon. Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes). Journal of Biomarkers. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492382