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Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, and tissue homeostasis in organs where they are expressed.
Recently, their roles in stem cell and cancer biology are emerging.
In the thyroid, NKX2-1, FOXE1, and PAX8 transcription factors are responsible for thyroid organogenesis and expression of thyroid-specific genes critical for thyroid hormone synthesis.
In contrast to their known roles in gene regulation, thyroid development and homeostasis, their involvement in stem cell, and/or cancer biology are still elusive.
In order to further understand the nature of thyroid cancer, it is critical to determine their roles in thyroid cancer.
American Psychological Association (APA)
Kimura, Shioko. 2011. Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492408
Modern Language Association (MLA)
Kimura, Shioko. Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer. Journal of Thyroid Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-492408
American Medical Association (AMA)
Kimura, Shioko. Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492408