Development of Nephrotic Syndrome after Administration of Sorafenib in a Case of Metastatic Renal Cell Carcinoma

Abstract EN

Nephrotic syndrome, after administration of tyrosine kinase inhibitors, is uncommon and not well known.

A 62-year-old male, who had experienced a left nephrectomy due to a traffic accident 38 years ago, underwent a partial nephrectomy for right renal cell carcinoma (RCC).

Histologically, the tumor was a clear cell RCC.

Two years later abdominal CT revealed para-aortic lymph node metastasis.

During these two years, serum creatinine had increased from 2.0 mg/dL to 2.9 mg/dL along with the appearance of proteinuria.

After only a week of sorafenib, 400 mg/day, fever developed and sorafenib was stopped.

Although normotensive, his serum creatinine increased to 3.83 mg/dL and serum albumin decreased from 1.8 g/L to 1.0 g/L.

Proteinuria also worsened to 27.5 g/day.

He became edematous, and ascites and cardiac effusions also appeared.

He was diagnosed with nephrotic syndrome.

A retrospective review of the histology of the partial nephrectomy revealed no change in the glomeruli.