Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps
Joint Authors
Klinger, Matthias
Möller, Sonja
Laskay, Tamás
Behnen, Martina
Solbach, Werner
Hermann, Eva
Kirchner, Tina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases.
Since NET-formation in response to several biological and chemical stimuli is mostly ROS dependent, in theory any substance that inhibits or scavenges ROS could prevent ROS-dependent NET release.
Therefore, in the present comprehensive study, several antioxidative substances were assessed for their capacity to inhibit NET formation of primary human neutrophils in vitro.
We could show that the flavonoids (−)-epicatechin, (+)-catechin hydrate, and rutin trihydrate as well as vitamin C and the pharmacological substances N-acetyl-L-cysteine and 5-aminosalicylic acid inhibited PMA induced ROS production and NET formation.
Therefore, a broad spectrum of antioxidative substances that reduce ROS production of primary human neutrophils also inhibits ROS-dependent NET formation.
It is tempting to speculate that such antioxidants can have beneficial therapeutic effects in diseases associated with ROS-dependent NET formation.
American Psychological Association (APA)
Kirchner, Tina& Hermann, Eva& Möller, Sonja& Klinger, Matthias& Solbach, Werner& Laskay, Tamás…[et al.]. 2013. Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492412
Modern Language Association (MLA)
Kirchner, Tina…[et al.]. Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps. Mediators of Inflammation No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-492412
American Medical Association (AMA)
Kirchner, Tina& Hermann, Eva& Möller, Sonja& Klinger, Matthias& Solbach, Werner& Laskay, Tamás…[et al.]. Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492412