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Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome : A Case Report and Review of the Literature
Joint Authors
Routy, B.
Fraser, R.
Huynh, T.
Séguin, C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Catastrophic antiphospholipid syndrome (CAPS) is a rare autoimmune condition, which has been associated with a high mortality rate.
However, with current management that includes a combination of anticoagulation, glucocorticoid administration, and plasma exchange, mortality rate has declined.
Despite survival improvement with new generation immunosuppressive agents, their mechanisms of action are poorly defined, and CAPS is still considered a high-risk complication in patients known with antiphospholipid antibody syndrome.
Herein, we present a case of a 79-year-old male who presented with a myocardial infarct and renal failure secondary to CAPS following a splenectomy for immune thrombocytopenia.
Regardless of rapid combination of first-line treatment and rituximab therapy, the patient developed lethal cardiogenic shock secondary to mitral valve papillary muscle necrosis.
Discussion of the pathophysiology and avenues of future therapies in CAPS are reported.
American Psychological Association (APA)
Routy, B.& Huynh, T.& Fraser, R.& Séguin, C.. 2013. Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome : A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-492426
Modern Language Association (MLA)
Routy, B.…[et al.]. Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome : A Case Report and Review of the Literature. Case Reports in Hematology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-492426
American Medical Association (AMA)
Routy, B.& Huynh, T.& Fraser, R.& Séguin, C.. Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome : A Case Report and Review of the Literature. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-492426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492426