Toll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease
Joint Authors
Mandrekar, Pranoti
Szabo, Gyongyi
Petrasek, Jan
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role.
Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD.
In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4.
The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated.
The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.
American Psychological Association (APA)
Petrasek, Jan& Mandrekar, Pranoti& Szabo, Gyongyi. 2010. Toll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-492428
Modern Language Association (MLA)
Petrasek, Jan…[et al.]. Toll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease. Gastroenterology Research and Practice No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-492428
American Medical Association (AMA)
Petrasek, Jan& Mandrekar, Pranoti& Szabo, Gyongyi. Toll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-492428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492428
