Near-Full Genome Characterisation of Two Natural Intergenotypic 2k1b Recombinant Hepatitis C Virus Isolates
Joint Authors
Demetriou, Victoria L.
Kyriakou, Eftychia
Kostrikis, Leondios G.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Few natural intergenotypic hepatitis C virus (HCV) recombinants have been characterised, and only RF1_2k/1b has demonstrated widespread transmission.
The near-full length genome sequences for two cases of 2k/1b recombinants (CYHCV037 and CYHCV093) sampled in Cyprus were obtained using strain-specific RT-PCR amplification and sequencing protocols.
Sequence analysis confirmed their similarity with the original RF1_2k/1b strain from St.
Petersburg, N687.
These two isolates significantly contribute to the sequence data available on this recombinant and confirm its increasing spread among individuals from Eastern Europe, and its association with transmission through intravenous drug use.
Phylogenetic analyses reveal clustering of the sequence 3′ to the recombination point, not seen in the topology of the 5′ sequences, implying a more complicated evolutionary history than that held to date.
The increasing cases of HCV recombinant strains underline the requirement of their contribution to the standardised rules of HCV classification and nomenclature, molecular epidemiology, diagnosis, and treatment.
American Psychological Association (APA)
Demetriou, Victoria L.& Kyriakou, Eftychia& Kostrikis, Leondios G.. 2011. Near-Full Genome Characterisation of Two Natural Intergenotypic 2k1b Recombinant Hepatitis C Virus Isolates. Advances in Virology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492437
Modern Language Association (MLA)
Demetriou, Victoria L.…[et al.]. Near-Full Genome Characterisation of Two Natural Intergenotypic 2k1b Recombinant Hepatitis C Virus Isolates. Advances in Virology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-492437
American Medical Association (AMA)
Demetriou, Victoria L.& Kyriakou, Eftychia& Kostrikis, Leondios G.. Near-Full Genome Characterisation of Two Natural Intergenotypic 2k1b Recombinant Hepatitis C Virus Isolates. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492437