![](/images/graphics-bg.png)
Targeted Treatments for Restenosis and Vein Graft Disease
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Surgery to restore blood flow in arteries blocked by atherosclerotic plaque is a common treatment in cardiovascular disease.
Long-term complications of surgical treatment are vein graft disease and restenosis, a renarrowing of the blood vessel after bypass or removal of the culprit atherosclerotic plaque.
Attempts to prevent or treat these complications by systemic pharmacological approaches have been largely unsuccessful in the clinic.
This has led to an interest in developing targeted or locally delivered strategies.
This paper discusses many of the various site-delivered therapies that are under examination as potential antirestenotic and antivein graft disease agents (including antithrombotic, antiproliferative, and anti-inflammatory agents) and why many therapies developed in animal models fail in clinical trials.
Techniques of targeted delivery (including stents, “magic bullets,” and adventitial delivery) and delivery systems (including nanoparticles and the use of gene therapy) are also discussed.
American Psychological Association (APA)
Thomas, Anita C.. 2012. Targeted Treatments for Restenosis and Vein Graft Disease. ISRN Vascular Medicine،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-492466
Modern Language Association (MLA)
Thomas, Anita C.. Targeted Treatments for Restenosis and Vein Graft Disease. ISRN Vascular Medicine No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-492466
American Medical Association (AMA)
Thomas, Anita C.. Targeted Treatments for Restenosis and Vein Graft Disease. ISRN Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-492466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492466