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Atrial Natriuretic Peptide and Renal Dopaminergic System : A Positive Friendly Relationship?
Joint Authors
Kravetz, María Cecilia
Choi, Marcelo Roberto
Kouyoumdzian, Nicolás Martín
Fernández, Belisario Enrique
Rukavina Mikusic, Natalia Lucía
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors.
Renal dopamine plays a central role in this interactive network.
The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system.
Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide.
At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na+, K+-ATPase activity.
In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems.
The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.
American Psychological Association (APA)
Choi, Marcelo Roberto& Rukavina Mikusic, Natalia Lucía& Kouyoumdzian, Nicolás Martín& Kravetz, María Cecilia& Fernández, Belisario Enrique. 2014. Atrial Natriuretic Peptide and Renal Dopaminergic System : A Positive Friendly Relationship?. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492468
Modern Language Association (MLA)
Choi, Marcelo Roberto…[et al.]. Atrial Natriuretic Peptide and Renal Dopaminergic System : A Positive Friendly Relationship?. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-492468
American Medical Association (AMA)
Choi, Marcelo Roberto& Rukavina Mikusic, Natalia Lucía& Kouyoumdzian, Nicolás Martín& Kravetz, María Cecilia& Fernández, Belisario Enrique. Atrial Natriuretic Peptide and Renal Dopaminergic System : A Positive Friendly Relationship?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492468