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Development of a Novel Embedded Relay Lens Microscopic Hyperspectral Imaging System for Cancer Diagnosis : Use of the Mice with Oral Cancer to Be the Example
Joint Authors
Chiou, Jun-Chern
Tsai, Ming-Hsui
Chang, Nai-Wen
Lin, Yung-Jiun
Lee, Cheng-Chung
Wu, Shuen-De
Hsieh, Yao-Fang
Jan, Chia-Ing
Duann, Jeng-Ren
Ou-Yang, Mang
Source
International Journal of Spectroscopy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This paper develops a novel embedded relay lens microscopic hyperspectral imaging system (ERL-MHSI) with high spectral resolution (nominal spectral resolution of 2.8 nm) and spatial resolution (30 μm × 10 μm) for cancer diagnosis.
The ERL-MHSI system has transmittance and fluorescence mode.
The transmittance can provide the morphological information for pathological diagnosis, and the fluorescence of cells or tissue can provide the characteristic signature for identification of normal and abnormal.
In this work, the development of the ERL-MHSI system is discussed and the capability of the system is demonstrated by diagnosing early stage oral cancer of twenty mice in vitro.
The best sensitivity for identifying normal cells and squamous cell carcinoma (SCC) was 100%.
The best specificity for identifying normal cells and SCC was 99%.
The best sensitivity for identifying normal cells and dysplasia was 99%.
The best specificity for identifying normal cells and dysplasia was 97%.
This work also utilizes fractal dimension to analyze the morphological information and find the significant different values between normal and SCC.
American Psychological Association (APA)
Hsieh, Yao-Fang& Ou-Yang, Mang& Duann, Jeng-Ren& Chiou, Jun-Chern& Chang, Nai-Wen& Jan, Chia-Ing…[et al.]. 2012. Development of a Novel Embedded Relay Lens Microscopic Hyperspectral Imaging System for Cancer Diagnosis : Use of the Mice with Oral Cancer to Be the Example. International Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-492470
Modern Language Association (MLA)
Hsieh, Yao-Fang…[et al.]. Development of a Novel Embedded Relay Lens Microscopic Hyperspectral Imaging System for Cancer Diagnosis : Use of the Mice with Oral Cancer to Be the Example. International Journal of Spectroscopy No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-492470
American Medical Association (AMA)
Hsieh, Yao-Fang& Ou-Yang, Mang& Duann, Jeng-Ren& Chiou, Jun-Chern& Chang, Nai-Wen& Jan, Chia-Ing…[et al.]. Development of a Novel Embedded Relay Lens Microscopic Hyperspectral Imaging System for Cancer Diagnosis : Use of the Mice with Oral Cancer to Be the Example. International Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-492470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492470