![](/images/graphics-bg.png)
Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease
Joint Authors
Drzezga, Alexander
Yousefi, Behrooz H.
Henriksen, Gjermund
Tsolakidou, Amalia
Sorg, Christian
Grimmer, Timo
Förstl, Hans
Kurz, Alexander
Perneczky, Robert
Guo, Liang-Hao
Alexopoulos, Panagiotis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The secretase BACE1 is fundamentally involved in the development of cerebral amyloid pathology in Alzheimer's disease (AD).
It has not been studied so far to what extent BACE1 activity in cerebrospinal fluid (CSF) mirrors in vivo amyloid load in AD.
We explored associations between CSF BACE1 activity and fibrillar amyloid pathology as measured by carbon-11-labelled Pittsburgh Compound B positron emission tomography ([11C]PIB PET).
[11C]PIB and CSF studies were performed in 31 patients with AD.
Voxel-based linear regression analysis revealed significant associations between CSF BACE1 activity and [11C]PIB tracer uptake in the bilateral parahippocampal region, the thalamus, and the pons.
Our study provides evidence for a brain region-specific correlation between CSF BACE1 activity and in-vivo fibrillar amyloid pathology in AD.
Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring.
American Psychological Association (APA)
Grimmer, Timo& Alexopoulos, Panagiotis& Tsolakidou, Amalia& Guo, Liang-Hao& Henriksen, Gjermund& Yousefi, Behrooz H.…[et al.]. 2012. Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492499
Modern Language Association (MLA)
Grimmer, Timo…[et al.]. Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-492499
American Medical Association (AMA)
Grimmer, Timo& Alexopoulos, Panagiotis& Tsolakidou, Amalia& Guo, Liang-Hao& Henriksen, Gjermund& Yousefi, Behrooz H.…[et al.]. Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492499