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Effects of IGF-1 on IK and IK1 Channels via PI3KAkt Signaling in Neonatal Cardiac Myocytes
Joint Authors
Haddad, Georges E.
Alvin, Zikiar V.
Zhao, Aiqiu
Millis, Richard M.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Previous studies suggest that sarcolemmal potassium currents play important roles in cardiac hypertrophy.
IGF-1 contributes to cardiac hypertrophy via activation of PI3K/Akt signaling.
However, the relationships between IGF-1, PI3K/Akt signaling and sarcolemmal potassium currents remain unknown.
Therefore, we tested the hypothesis that IGF-1 and PI3K/Akt signaling, independently, decrease sarcolemmal potassium currents in cardiac myocytes of neonatal rats.
We compared the delayed outward rectifier (IK) and the inward rectifier (IK) current densities resulting from IGF-1 treatments to those resulting from simulation of PI3K/Akt signaling using adenoviral (Ad) BD110 and wild-type Akt and to those resulting from inhibition of PI3K signaling by LY294002.
Ad.BD110 and Ad.Akt decreased IK and these decrements were attenuated by LY 294002.
The IGF-1 treatments decreased both IK and IK1 but only the IK decrement was attenuated by LY294002.
These findings demonstrate that IGF-1 may contribute to cardiac hypertrophy by PI3K/Akt signal transduction mechanisms in neonatal rat cardiomyocytes.
Failure of LY294002 to effectively antagonize IGF-1 induced decrements in IK1 suggests that a signal pathway adjunct to PI3K/Akt contributes to IGF-1 protection against arrhythmogenesis in these myocytes.
Our findings imply that sarcolemmal outward and inward rectifier potassium channels are substrates for IGF-1/PI3K/Akt signal transduction molecules.
American Psychological Association (APA)
Millis, Richard M.& Alvin, Zikiar V.& Zhao, Aiqiu& Haddad, Georges E.. 2012. Effects of IGF-1 on IK and IK1 Channels via PI3KAkt Signaling in Neonatal Cardiac Myocytes. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492510
Modern Language Association (MLA)
Millis, Richard M.…[et al.]. Effects of IGF-1 on IK and IK1 Channels via PI3KAkt Signaling in Neonatal Cardiac Myocytes. International Journal of Cell Biology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-492510
American Medical Association (AMA)
Millis, Richard M.& Alvin, Zikiar V.& Zhao, Aiqiu& Haddad, Georges E.. Effects of IGF-1 on IK and IK1 Channels via PI3KAkt Signaling in Neonatal Cardiac Myocytes. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492510