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Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc
Joint Authors
Hicks, Juan Jose
Montoya-Estrada, Araceli
Acosta-Altamirano, Gustavo
Cueto, Jorge
Torres-Ramos, Yessica
Moreno-Eutimio, Mario Adan
Espinosa-Monroy, Lorena
Nieto-Velázquez, Nayeli Goreti
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses.
Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation.
However, the direct effects of Pebisut on isolated cells and acute inflammatory responses remained to be investigated.
The present study evaluated anti-inflammatory effect of Pebisut using lipopolysaccharide (LPS) stimulated human mononuclear cells, chemotaxis, and cell infiltration in vivo in a murine model of peritonitis.
Our data show that human cells treated with different dilutions of Pebisut release less IL-6, IL-1β, and IL-8 after LPS stimuli compared with the control treated cells.
In addition, Pebisut lacked chemotactic activity in human mononuclear cells but was able to reduce chemotaxis towards CCL2, CCL5, and CXCL12 that are representative mononuclear cells chemoattractants.
Finally, in a murine model of peritonitis, we found less number of macrophages (F4/80+) and T lymphocytes (CD3+) in peritoneal lavages from animals treated with Pebisut.
Our results suggest that Pebisut has anti-inflammatory activity, which might have a beneficial effect during anastomoses healing or wounds associated with excessive inflammation.
American Psychological Association (APA)
Moreno-Eutimio, Mario Adan& Nieto-Velázquez, Nayeli Goreti& Espinosa-Monroy, Lorena& Torres-Ramos, Yessica& Montoya-Estrada, Araceli& Cueto, Jorge…[et al.]. 2014. Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492515
Modern Language Association (MLA)
Moreno-Eutimio, Mario Adan…[et al.]. Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-492515
American Medical Association (AMA)
Moreno-Eutimio, Mario Adan& Nieto-Velázquez, Nayeli Goreti& Espinosa-Monroy, Lorena& Torres-Ramos, Yessica& Montoya-Estrada, Araceli& Cueto, Jorge…[et al.]. Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492515