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The Janus Face of Lipids in Human Breast Cancer : How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks
Joint Authors
Chénais, Benoît
Blanckaert, Vincent
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
For several years, lipids and especially n-3 and n-6 polyunsaturated fatty acids (PUFAs) receive much attention in human health.
Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer.
However, the molecular and cellular mechanisms supporting the effect of PUFAs in breast cancer cells remain relatively unknown.
Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion.
While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects.
Finally, lipids and especially PUFAs appear as potential adjuvants to conventional cancer therapy.
American Psychological Association (APA)
Chénais, Benoît& Blanckaert, Vincent. 2012. The Janus Face of Lipids in Human Breast Cancer : How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492539
Modern Language Association (MLA)
Chénais, Benoît& Blanckaert, Vincent. The Janus Face of Lipids in Human Breast Cancer : How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks. International Journal of Breast Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492539
American Medical Association (AMA)
Chénais, Benoît& Blanckaert, Vincent. The Janus Face of Lipids in Human Breast Cancer : How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492539