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Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients
Joint Authors
Schultz, Marcus J.
Royakkers, Annick A.
Kuiper, Michaël A.
Spronk, Peter E.
Korevaar, Joke C.
Bouman, Catherine S.
van de Hoek, Willem
Stassen, Pauline M.
Binnekade, Jan M.
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Neutrophil gelatinase-associated lipocalin (NGAL) in serum and urine have been suggested as potential early predictive biological markers of acute kidney injury (AKI) in selected critically ill patients.
Methods.
We performed a secondary analysis of a multicenter prospective observational cohort study of unselected critically ill patients.
Results.
The analysis included 140 patients, including 57 patients who did not develop AKI, 31 patients who developed AKI, and 52 patients with AKI on admission to the ICU.
Levels of sNGAL and uNGAL on non-AKI days were significantly lower compared to levels of sNGAL on RIFLERISK days, RIFLEINJURY days, and RIFLEFAILURE days.
The AUC of sNGAL for predicting AKI was low: 0.45 (95% confidence interval (CI) 0.27–0.63) and 0.53 (CI 0.38–0.67), 2 days and 1 day before development of AKI, respectively.
The AUC of uNGAL for predicting AKI was also low: 0.48 (CI 0.33–0.62) and 0.48 (CI 0.33–0.62), 2 days and 1 day before development of AKI, respectively.
AUC of sNGAL and uNGAL for the prediction of renal replacement therapy requirement was 0.47 (CI 0.37–0.58) and 0.26 (CI 0.03–0.50).
Conclusions.
In unselected critically ill patients, sNGAL and uNGAL are poor predictors of AKI or RRT.
American Psychological Association (APA)
Royakkers, Annick A.& Bouman, Catherine S.& Stassen, Pauline M.& Korevaar, Joke C.& Binnekade, Jan M.& van de Hoek, Willem…[et al.]. 2012. Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492557
Modern Language Association (MLA)
Royakkers, Annick A.…[et al.]. Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients. Critical Care Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492557
American Medical Association (AMA)
Royakkers, Annick A.& Bouman, Catherine S.& Stassen, Pauline M.& Korevaar, Joke C.& Binnekade, Jan M.& van de Hoek, Willem…[et al.]. Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492557