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Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial
Joint Authors
Moilanen, Eeva
Pettilä, Ville
Mentula, Panu
Kylanpaa, Marja-Leena
Puolakkainen, Pauli
Repo, Heikki
Kyhälä, Lea
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study aimed to determine the effect of the activated protein C on the course of systemic inflammation in the APCAP (activated protein C in acute pancreatitis) trial where we randomized 32 patients with severe acute pancreatitis to receive either recombinant activated protein C (drotrecogin alfa activated) (n=16) or placebo (n=16) for 96 hours.
In the present study, we present the time course of the patients’ plasma or serum levels of soluble markers (IL-8, IL-6, IL-10, IL-1ra, sE-selectin, PCT) and monocyte and neutrophil cell surface (CD11b, CD14, CD62L, HLA-DR) markers of systemic inflammatory response during the first 14 days after the randomization.
The results of the intervention and placebo groups were comparable showing that recombinant APC treatment did not alter the course of systemic inflammation in severe acute pancreatitis.
Our finding is in accordance with the clinical findings in the APCAP trial indicating that the intervention did not affect evolution of multiple organ dysfunctions.
American Psychological Association (APA)
Kyhälä, Lea& Mentula, Panu& Kylanpaa, Marja-Leena& Moilanen, Eeva& Puolakkainen, Pauli& Pettilä, Ville…[et al.]. 2012. Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492565
Modern Language Association (MLA)
Kyhälä, Lea…[et al.]. Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial. International Journal of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492565
American Medical Association (AMA)
Kyhälä, Lea& Mentula, Panu& Kylanpaa, Marja-Leena& Moilanen, Eeva& Puolakkainen, Pauli& Pettilä, Ville…[et al.]. Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492565