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What We Have Learned about Autism Spectrum Disorder from Valproic Acid
Joint Authors
Hu, Bin
Turner, Nathanael
Chomiak, Taylor
Source
Pathology Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Two recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular.
Parallel to this work, there is a growing body of animal research literature using VPA as an animal model of ASD.
In this focused review we first summarize the epidemiological evidence linking VPA to ASD and then comment on two important neurobiological findings linking VPA to ASD clinicopathology, namely, accelerated or early brain overgrowth and hyperexcitable networks.
Improving our understanding of how the drug VPA can alter early development of neurological systems will ultimately improve our understanding of ASD.
American Psychological Association (APA)
Chomiak, Taylor& Turner, Nathanael& Hu, Bin. 2013. What We Have Learned about Autism Spectrum Disorder from Valproic Acid. Pathology Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492569
Modern Language Association (MLA)
Chomiak, Taylor…[et al.]. What We Have Learned about Autism Spectrum Disorder from Valproic Acid. Pathology Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-492569
American Medical Association (AMA)
Chomiak, Taylor& Turner, Nathanael& Hu, Bin. What We Have Learned about Autism Spectrum Disorder from Valproic Acid. Pathology Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492569