Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation
Joint Authors
Wu, Rong-Tsun
Horng, Lin-Yea
Huang, Hui-Chuan
Sung, Hui-Ching
Peng, Kang-Yung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to evaluate the effect of an ethanol extract of the rhizomes of Dioscorea alata L.
cv.
Phyto, Dispo85E, on bone formation and to investigate the mechanisms involved.
Our results showed that Dispo85E increased the activity of alkaline phosphatase (ALP) and bone nodule formation in primary bone marrow cultures.
In addition, Dispo85E stimulated pluripotent C3H10T1/2 stem cells to differentiate into osteoblasts rather than adipocytes.
Our in vivo data indicated that Dispo85E promotes osteoblastogenesis by increasing ALP activity and bone nodule formation in both intact and ovariectomized (OVX) mice.
Microcomputed tomography (μCT) analysis also showed that Dispo85E ameliorates the deterioration of trabecular bone mineral density (tBMD), trabecular bone volume/total volume (BV/TV), and trabecular bone number (Tb.N) in OVX mice.
Our results suggested that Dispo85E is a botanical drug with a novel mechanism that drives the lineage-specific differentiation of bone marrow stromal cells and is a candidate drug for osteoporosis therapy.
American Psychological Association (APA)
Peng, Kang-Yung& Horng, Lin-Yea& Sung, Hui-Ching& Huang, Hui-Chuan& Wu, Rong-Tsun. 2011. Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-492582
Modern Language Association (MLA)
Peng, Kang-Yung…[et al.]. Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-492582
American Medical Association (AMA)
Peng, Kang-Yung& Horng, Lin-Yea& Sung, Hui-Ching& Huang, Hui-Chuan& Wu, Rong-Tsun. Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-492582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492582
