Hereditary Connective Tissue Diseases in Young Adult Stroke : A Comprehensive Synthesis

Abstract EN

Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults.

Besides arteriopathies and metabolic disorders, several connective tissue diseases can present with stroke.

While some of these diseases have been recognized for decades as causes of stroke, such as the vascular Ehlers-Danlos syndrome, others only recently came to attention as being involved in stroke pathogenesis, such as those related to Type IV collagen.

This paper discusses each of these connective tissue disorders and their relation with stroke briefly, emphasizing the main clinical features which can lead to their diagnosis.