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Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
Joint Authors
Kondo, Yasuteru
Shimosegawa, Tooru
Ueno, Yoshiyuki
Source
Hepatitis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Patients with chronic hepatitis C (CHC) virus infection who have persistently normal alanine aminotransferase levels (PNALT) have mild inflammation and fibrosis in comparison to those with elevated ALT levels.
The cellular immune responses to HCV are mainly responsible for viral clearance and the disease pathogenesis during infection.
However, since the innate and adaptive immune systems are suppressed by various kinds of mechanisms in CHC patients, the immunopathogenesis of CHC patients with PNALT is still unclear.
In this review, we summarize the representative reports about the immune suppression in CHC to better understand the immunopathogenesis of PNALT.
Then, we summarize and speculate on the immunological aspects of PNALT including innate and adaptive immune systems and genetic polymorphisms of HLA and cytokines.
American Psychological Association (APA)
Kondo, Yasuteru& Ueno, Yoshiyuki& Shimosegawa, Tooru. 2011. Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT. Hepatitis Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492603
Modern Language Association (MLA)
Kondo, Yasuteru…[et al.]. Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT. Hepatitis Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-492603
American Medical Association (AMA)
Kondo, Yasuteru& Ueno, Yoshiyuki& Shimosegawa, Tooru. Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT. Hepatitis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492603