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Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice
Joint Authors
Lapointe, Marc
Poursharifi, Pegah
Oikonomopoulou, Katerina
Cianflone, Katherine
Fisette, Alexandre
Munkonda, Mercedes N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Acylation stimulating protein (ASP) is an adipokine derived from the immune complement system, which stimulates fat storage and is typically increased in obesity, type 2 diabetes, and cardiovascular disease.
Using a diet-induced obesity (DIO) mouse model, the acute effects of ASP on energy metabolism and inflammatory processes in vivo were evaluated.
We hypothesized that ASP would specifically exert proinflammatory effects.
C57Bl/6 wild-type mice were put on a high-fat-high-sucrose diet for 12 weeks.
Mice were then subjected to both glucose and insulin tolerance tests, each manipulation being preceded by recombinant ASP or vehicle (control) bolus injection.
ASP supplementation increased whole-body glucose excursion, and this was accomplished with reduced concomitant insulin levels.
However, ASP did not directly alter insulin sensitivity.
ASP supplementation induced a proinflammatory phenotype, with higher levels of cytokines including IL-6 and TNF-α in plasma and in adipose tissue, liver, and skeletal muscle mRNA.
Additionally, ASP increased M1 macrophage content of these tissues.
ASP exerted a direct concentration-dependent role in the migration and M1 activation of cultured macrophages.
Altogether, the in vivo and in vitro experiments demonstrate that ASP plays a role in both energy metabolism and inflammation, with paradoxical whole-body glucose-sensitizing yet proinflammatory effects.
American Psychological Association (APA)
Fisette, Alexandre& Poursharifi, Pegah& Oikonomopoulou, Katerina& Munkonda, Mercedes N.& Lapointe, Marc& Cianflone, Katherine. 2013. Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-492615
Modern Language Association (MLA)
Fisette, Alexandre…[et al.]. Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-492615
American Medical Association (AMA)
Fisette, Alexandre& Poursharifi, Pegah& Oikonomopoulou, Katerina& Munkonda, Mercedes N.& Lapointe, Marc& Cianflone, Katherine. Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-492615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492615