Antifungal Resistance and New Strategies to Control Fungal Infections
Joint Authors
Ferrari, Selene
Vandeputte, Patrick
Coste, Alix T.
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice.
In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled.
In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed.
It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes.
This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes.
Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets.
In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals.
Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections.
Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.
American Psychological Association (APA)
Vandeputte, Patrick& Ferrari, Selene& Coste, Alix T.. 2011. Antifungal Resistance and New Strategies to Control Fungal Infections. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-492651
Modern Language Association (MLA)
Vandeputte, Patrick…[et al.]. Antifungal Resistance and New Strategies to Control Fungal Infections. International Journal of Microbiology No. 2012 (2012), pp.1-26.
https://search.emarefa.net/detail/BIM-492651
American Medical Association (AMA)
Vandeputte, Patrick& Ferrari, Selene& Coste, Alix T.. Antifungal Resistance and New Strategies to Control Fungal Infections. International Journal of Microbiology. 2011. Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-492651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492651