Endocrine-Disrupting Chemicals : Associated Disorders and Mechanisms of Action
Joint Authors
van Larebeke, Nicolas
De Coster, Sam
Source
Journal of Environmental and Public Health
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-52, 52 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
52
Main Subjects
Abstract EN
The incidence and/or prevalence of health problems associated with endocrine-disruption have increased.
Many chemicals have endocrine-disrupting properties, including bisphenol A, some organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, pesticides, polycyclic aromatic hydrocarbons, alkylphenols, solvents, and some household products including some cleaning products, air fresheners, hair dyes, cosmetics, and sunscreens.
Even some metals were shown to have endocrine-disrupting properties.
Many observations suggesting that endocrine disruptors do contribute to cancer, diabetes, obesity, the metabolic syndrome, and infertility are listed in this paper.
An overview is presented of mechanisms contributing to endocrine disruption.
Endocrine disruptors can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway or modulation of nitric oxide.
In addition, changes in metabolism of endogenous hormones, cross-talk between genomic and nongenomic pathways, cross talk with estrogen receptors after binding on other receptors, interference with feedback regulation and neuroendocrine cells, changes in DNA methylation or histone modifications, and genomic instability by interference with the spindle figure can play a role.
Also it was found that effects of receptor activation can differ in function of the ligand.
American Psychological Association (APA)
De Coster, Sam& van Larebeke, Nicolas. 2012. Endocrine-Disrupting Chemicals : Associated Disorders and Mechanisms of Action. Journal of Environmental and Public Health،Vol. 2012, no. 2012, pp.1-52.
https://search.emarefa.net/detail/BIM-492652
Modern Language Association (MLA)
De Coster, Sam& van Larebeke, Nicolas. Endocrine-Disrupting Chemicals : Associated Disorders and Mechanisms of Action. Journal of Environmental and Public Health No. 2012 (2012), pp.1-52.
https://search.emarefa.net/detail/BIM-492652
American Medical Association (AMA)
De Coster, Sam& van Larebeke, Nicolas. Endocrine-Disrupting Chemicals : Associated Disorders and Mechanisms of Action. Journal of Environmental and Public Health. 2012. Vol. 2012, no. 2012, pp.1-52.
https://search.emarefa.net/detail/BIM-492652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492652