![](/images/graphics-bg.png)
Chronic Inflammation and Malignancy in Ulcerative Colitis
Joint Authors
Sunkara, Sai
Forsyth, Christopher B.
Keshavarzian, Ali
Swanson, Garth
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) associated with multiple colonic and extraintestinal complications, the most severe being the development of colorectal cancer (CRC).
Compared to the general population, there is an increased risk of CRC associated with UC.
Although the pathogenesis of CRC in UC is unknown, most studies have linked it to long-standing inflammation as well as other risk factors such as duration of disease, extent of inflammation, family history of CRC, and coexisting conditions such as primary sclerosing cholangitis (PSC).
UC is a life-long disease for which patients enter a vigilant screening program which includes surveillance colonoscopy to promote early detection of CRC yet some controversies exist regarding the cost effectiveness of surveillance colonoscopy and improving survival.
Newer modalities such as chromoendoscopy, narrow band imaging, high definition colonoscopy, and confocal microscopy have aided in developing a more targeted approach for early detection of dysplasia in surveillance colonoscopy.
This review focuses on the role of chronic colonic inflammation and dysplasia in development of UC-associated CRC and current methods of screening, detection, chemoprevention, and treatment of UC-associated CRC.
American Psychological Association (APA)
Sunkara, Sai& Swanson, Garth& Forsyth, Christopher B.& Keshavarzian, Ali. 2011. Chronic Inflammation and Malignancy in Ulcerative Colitis. Ulcers،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492679
Modern Language Association (MLA)
Sunkara, Sai…[et al.]. Chronic Inflammation and Malignancy in Ulcerative Colitis. Ulcers No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-492679
American Medical Association (AMA)
Sunkara, Sai& Swanson, Garth& Forsyth, Christopher B.& Keshavarzian, Ali. Chronic Inflammation and Malignancy in Ulcerative Colitis. Ulcers. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-492679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492679