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Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant
Joint Authors
Mohd, Mustafa Ali
Einstein, John Wilking
Rais Mustafa, Mohd
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The hypoglycemic effect of the methanolic and aqueous extracts of whole parts of Cassia fistula in both normoglycemic and streptozotocin-nictotinamide induced Type 2 diabetic rats were investigated.
Acute toxicity, oral glucose tolerance test and glucose uptake in isolated rat hemidiaphragm were performed in normal rats.
Diabetes was induced in Sprague Dawley rats by the administration of streptozotocin-nictotinamide (50, 110 mg/kg b.w., resp.) intraperitoneally.
Different extracts of Cassia was administered to diabetic rats at 250 and 500 mg/kg doses for 21 days.
Biochemical parameters like blood glucose, insulin, glycosylated hemoglobin, lipid profile, and serum marker enzymes were determined.
The methanolic extract of the bark and leaves were show more effective in causing hypoglycemia in normoglycemic rats.
Diabetic rats showed increased levels of glycosylated hemoglobin, reduced levels of plasma insulin, were significantly reverted to near normal after oral administration of the bark and leaf methanolic extracts.
Glucose uptake studies in isolated rat hemidiaphragm have shown enhanced peripheral utilization of glucose.
Chronic treatment of Cassia remarkably restored the normal status of the histopathological changes observed in the selected tissues.
Dose dependent anti-diabetic effects with the cohorts receiving the methanolic extract of bark followed by leaves of Cassia was revealed.
American Psychological Association (APA)
Einstein, John Wilking& Rais Mustafa, Mohd& Mohd, Mustafa Ali. 2012. Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-492680
Modern Language Association (MLA)
Einstein, John Wilking…[et al.]. Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant. Journal of Chemistry No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-492680
American Medical Association (AMA)
Einstein, John Wilking& Rais Mustafa, Mohd& Mohd, Mustafa Ali. Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-492680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492680