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The Inhibitory Effect of Haloxylon salicornicum on Contraction of the Mouse Uterus
Joint Authors
Simpson, Ann M.
Ferro, Valerie A.
Saleem, Nabila H.
Gray, Alexander I.
Drummond, Robert M.
Igoli, John
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Haloxylon salicornicum (H.
salicornicum) is a plant that is frequently taken as a tea by Bedouin women in Egypt who are experiencing difficulties during pregnancy, as well as to provide relief from dysmenorrhoea.
Despite its medical use, there has been no detailed evaluation of the effect of this plant on uterine tissue.
Therefore, the initial aim of this study was to determine whether H.
salicornicum affected the contraction of the mouse uterus in vitro.
The crude aqueous extract of H.
salicornicum was found to inhibit the spontaneous contractions of the uterus, with the effect being rapid in onset and completely reversible upon washout.
Subsequent purification of the plant extract resulted in the identification of synephrine and N-methyltyramine, both of which were found to have inhibitory effects on the spontaneous contractions of the uterus.
The EC50 for the purified constituent identified as synephrine was 0.82 ± 0.24 μg/mL.
The inhibitory activity of crude H.
salicornicum, as well as the isolated constituents, could be prevented by pretreatment of the uterus with the β-adrenoceptor antagonist propranolol.
In conclusion, the use of H.
salicornicum during preterm labour appears to be justified, and its pharmacologic effect is consistent with it acting as a β-adrenoceptor agonist.
American Psychological Association (APA)
Saleem, Nabila H.& Ferro, Valerie A.& Simpson, Ann M.& Igoli, John& Gray, Alexander I.& Drummond, Robert M.. 2013. The Inhibitory Effect of Haloxylon salicornicum on Contraction of the Mouse Uterus. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-492682
Modern Language Association (MLA)
Saleem, Nabila H.…[et al.]. The Inhibitory Effect of Haloxylon salicornicum on Contraction of the Mouse Uterus. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-492682
American Medical Association (AMA)
Saleem, Nabila H.& Ferro, Valerie A.& Simpson, Ann M.& Igoli, John& Gray, Alexander I.& Drummond, Robert M.. The Inhibitory Effect of Haloxylon salicornicum on Contraction of the Mouse Uterus. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-492682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492682