Local Bone Marrow Renin-Angiotensin System and Atherosclerosis
Joint Authors
Guven, Gulay Sain
Haznedaroglu, Ibrahim C.
Beyazit, Yavuz
Purnak, Tugrul
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells.
Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states.
RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis.
Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis.
Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis.
The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.
American Psychological Association (APA)
Beyazit, Yavuz& Purnak, Tugrul& Guven, Gulay Sain& Haznedaroglu, Ibrahim C.. 2010. Local Bone Marrow Renin-Angiotensin System and Atherosclerosis. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-492717
Modern Language Association (MLA)
Beyazit, Yavuz…[et al.]. Local Bone Marrow Renin-Angiotensin System and Atherosclerosis. Cardiology Research and Practice No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-492717
American Medical Association (AMA)
Beyazit, Yavuz& Purnak, Tugrul& Guven, Gulay Sain& Haznedaroglu, Ibrahim C.. Local Bone Marrow Renin-Angiotensin System and Atherosclerosis. Cardiology Research and Practice. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-492717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492717