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Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants
Joint Authors
Faldella, Giacomo
Aceti, Arianna
Corvaglia, Luigi
Martini, Silvia
Monari, Caterina
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although gastroesophageal reflux (GER) is a very common phenomenon among preterm infants, its therapeutic management is still an issue of debate among neonatologists.
A step-wise approach should be advisable, firstly promoting nonpharmacological interventions and limiting drugs to selected infants unresponsive to the conservative measures or who are suffering from severe GER with clinical complications.
Despite of this, a concerning pharmacological overtreatment has been increasingly reported.
Most of the antireflux drugs, however, have not been specifically assessed in preterm infants; moreover, serious adverse effects have been noticed in association to their administration.
This review mainly aims to draw the state of the art regarding the pharmacological management of GER in preterm infants, analyzing the best piecies of evidence currently available on the most prescribed anti-reflux drugs.
Although further trials are required, sodium alginate-based formulations might be considered promising; however, data regarding their safety are still limited.
Few piecies of evidence on the efficacy of histamine-2 receptor blockers and proton pump inhibitors in preterm infants with GER are currently available.
Nevertheless, a significantly increased risk of necrotizing enterocolitis and infections has been largely reported in association with their use, thereby leading to an unfavorable risk-benefit ratio.
The efficacy of metoclopramide in GER’s improvement still needs to be clarified.
Other prokinetic agents, such as domperidone and erythromycin, have been reported to be ineffective, whereas cisapride has been withdrawn due to its remarkable cardiac adverse effects.
American Psychological Association (APA)
Corvaglia, Luigi& Monari, Caterina& Martini, Silvia& Aceti, Arianna& Faldella, Giacomo. 2013. Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-492720
Modern Language Association (MLA)
Corvaglia, Luigi…[et al.]. Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants. Gastroenterology Research and Practice No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-492720
American Medical Association (AMA)
Corvaglia, Luigi& Monari, Caterina& Martini, Silvia& Aceti, Arianna& Faldella, Giacomo. Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-492720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492720