Arginine and Nitric Oxide Pathways in Obesity-Associated Asthma
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Obesity is a comorbidity that adversely affects asthma severity and control by mechanisms that are not fully understood.
This review will discuss evidence supporting a role for nitric oxide (NO) as a potential mechanistic link between obesity and late-onset asthma (>12 years).
Several studies have shown that there is an inverse association between increasing body mass index (BMI) and reduced exhaled NO.
Newer evidence suggests that a potential explanation for this paradoxical relationship is related to nitric oxide synthase (NOS) uncoupling, which occurs due to an imbalance between L-arginine (NOS substrate) and its endogenous inhibitor, asymmetric di-methyl arginine (ADMA).
The review will propose a theoretical framework to understand the relevance of this pathway and how it may differ between early and late-onset obese asthmatics.
Finally, the paper will discuss potential new therapeutic approaches, based on these paradigms, for improving the respiratory health of obese subjects with asthma.
American Psychological Association (APA)
Holguin, Fernando. 2013. Arginine and Nitric Oxide Pathways in Obesity-Associated Asthma. Journal of Allergy،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-492723
Modern Language Association (MLA)
Holguin, Fernando. Arginine and Nitric Oxide Pathways in Obesity-Associated Asthma. Journal of Allergy No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-492723
American Medical Association (AMA)
Holguin, Fernando. Arginine and Nitric Oxide Pathways in Obesity-Associated Asthma. Journal of Allergy. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-492723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492723