Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus
Joint Authors
Yu, Shui-Lian
Li, Edmund K.
Wong, Chun-Kwok
Tam, Lai-Shan
Kuan, Woon-Pang
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology affecting more than one million individuals each year.
It is characterized by B- and T-cell hyperactivity and by defects in the clearance of apoptotic cells and immune complexes.
Understanding the complex process involved and the interaction between various cytokines, chemokines, signaling molecules, and pattern-recognition receptors (PRRs) in the immune pathways will provide valuable information on the development of novel therapeutic targets for treating SLE.
In this paper, we review the immunopathological roles of novel cytokines, chemokines, signaling molecules, PRRs, and their interactions in immunoregulatory networks and suggest how their disturbances may implicate pathological conditions in SLE.
American Psychological Association (APA)
Yu, Shui-Lian& Kuan, Woon-Pang& Wong, Chun-Kwok& Li, Edmund K.& Tam, Lai-Shan. 2012. Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-492777
Modern Language Association (MLA)
Yu, Shui-Lian…[et al.]. Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-492777
American Medical Association (AMA)
Yu, Shui-Lian& Kuan, Woon-Pang& Wong, Chun-Kwok& Li, Edmund K.& Tam, Lai-Shan. Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-492777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492777