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Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers
Joint Authors
Musyoki, Stanslaus
Nyongesa, Paul
Mining, Simeon
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
To date the effect of pregnancy on the immune activation of CD8 T cells that may affect HIV disease progression has not been well studied and remains unclear.
Objective.
To determine the effect of pregnancy on CD8 T lymphocyte activation and its relationship with CD4 count in HIV infected pregnant women.
Study Design.
Case control.
Study Site.
AMPATH and MTRH in Eldoret, Kenya.
Study Subjects.
Newly diagnosed asymptomatic HIV positive pregnant and nonpregnant women with no prior receipt of antiretroviral medications.
Study Methods.
Blood samples were collected from the study participants and levels of activated CD8 T lymphocytes (CD38 and HLA-DR) were determined using flow cytometer and correlated with CD4 counts of the study participants.
The descriptive data focusing on frequencies, correlation, and cross-tabulations was statistically determined.
Significance of the results was set at P<0.05.
Results.
HIV positive pregnant women had lower activated CD8 T lymphocyte counts than nonpregnant HIV positive women.
Activated CD8 T lymphocyte counts were also noted to decrease in the second and third trimesters of pregnancy.
Conclusion.
Pregnancy has a significant suppression on CD8+ T lymphocyte immune activation during HIV infections.
Follow-up studies with more control arms could confirm the present study results.
American Psychological Association (APA)
Musyoki, Stanslaus& Mining, Simeon& Nyongesa, Paul. 2014. Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-492789
Modern Language Association (MLA)
Musyoki, Stanslaus…[et al.]. Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers. Interdisciplinary Perspectives on Infectious Diseases No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-492789
American Medical Association (AMA)
Musyoki, Stanslaus& Mining, Simeon& Nyongesa, Paul. Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers. Interdisciplinary Perspectives on Infectious Diseases. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-492789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492789