Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population
Joint Authors
Han, Dug-Yeo
Morgan, Angharad R.
Ferguson, Lynnette R.
Lam, Wen-Jiun
Fraser, Alan G.
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The gene ULK1 is an excellent candidate for Crohn’s disease (CD) due to its role in autophagy.
A recent study provided evidence for the involvement of ULK1 in the pathogenesis of CD (Henckaerts et al., 2011).
We attempted to validate this association, using a candidate gene SNP study of ULK1 in CD.
We identified tagging SNPs and genotyped these SNPs using the Sequenom platform in a Caucasian New Zealand dataset consisting of 406 CD patients and 638 controls.
In this sample, we were able to demonstrate an association between CD and several different ULK1 SNPs and haplotypes.
Phenotypic analysis showed an association with age of diagnosis 17–40 years and inflammatory behaviour.
The findings of this study provide evidence to suggest that genetic variation in ULK1 may play a role in interindividual differences in CD susceptibility and clinical outcome.
American Psychological Association (APA)
Morgan, Angharad R.& Lam, Wen-Jiun& Han, Dug-Yeo& Fraser, Alan G.& Ferguson, Lynnette R.. 2012. Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492792
Modern Language Association (MLA)
Morgan, Angharad R.…[et al.]. Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-492792
American Medical Association (AMA)
Morgan, Angharad R.& Lam, Wen-Jiun& Han, Dug-Yeo& Fraser, Alan G.& Ferguson, Lynnette R.. Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-492792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492792