2-Cys Peroxiredoxins : Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks

Joint Authors

Park, Jinah
Kang, Sang Won
Lee, Sanghyuk
Lee, Sunmi

Source

International Journal of Cell Biology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-02-04

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins.

Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2.

In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase.

These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders.

However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule.

These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.

American Psychological Association (APA)

Park, Jinah& Lee, Sunmi& Lee, Sanghyuk& Kang, Sang Won. 2014. 2-Cys Peroxiredoxins : Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492848

Modern Language Association (MLA)

Park, Jinah…[et al.]. 2-Cys Peroxiredoxins : Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks. International Journal of Cell Biology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-492848

American Medical Association (AMA)

Park, Jinah& Lee, Sunmi& Lee, Sanghyuk& Kang, Sang Won. 2-Cys Peroxiredoxins : Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492848

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492848