Decreased Bone Mineral Density in Patients Submitted to Kidney Transplantation Is Related to Age, Body Mass Index, Time on Dialysis, and Hyperparathyroidism
Joint Authors
Madeira, Miguel
Torres, Carolina Hammes
Lacativa, Paulo Gustavo Sampaio
Gonçalves, Renato Torres
de Mendonça, Laura Maria Carvalho
Lázaro, Ana Paula Pires
Zen, Mário Sérgio
de Farias, Maria Lucia Fleiuss
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Renal transplantation (Tx) influences bone mineral density (BMD) by several mechanisms.
The main objective of this study was to correlate BMD and risk factors associated with bone loss in patients submitted to kidney Tx.
Methods.
We evaluated 88 individuals after renal Tx (median time = 31.5 months since Tx).
All of them sustained glomerular filtration rate ≥60 mL/min/1.73 m2.
BMD was measured by dual-energy X-ray absorptiometry (DXA, Prodigy-GE).
Calcium, phosphate, albumin, creatinine, and intact parathormone (PTH) were measured at the same time.
All statistical tests were two-sided and P value less than 0.05 were accepted as significant for all analyses in this study.
Results.
Serum PTH was raised in 42% patients, but corrected calcium was normal in 83 patients.
No fragility fracture was reported, but the overall prevalence of osteoporosis was 27.6% and lower than expected BMD (Z-score ≤ −2.0 SD) was observed in 28.4%.
Patients with lower than expected BMD had higher PTH levels.
Conclusions.
Older age, lower body mass index (BMI), longer time on dialysis, and elevated PTH levels were identified as the main factors associated with lower BMD.
American Psychological Association (APA)
Madeira, Miguel& Zen, Mário Sérgio& Lacativa, Paulo Gustavo Sampaio& Torres, Carolina Hammes& Lázaro, Ana Paula Pires& Gonçalves, Renato Torres…[et al.]. 2014. Decreased Bone Mineral Density in Patients Submitted to Kidney Transplantation Is Related to Age, Body Mass Index, Time on Dialysis, and Hyperparathyroidism. Advances in Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-492866
Modern Language Association (MLA)
Madeira, Miguel…[et al.]. Decreased Bone Mineral Density in Patients Submitted to Kidney Transplantation Is Related to Age, Body Mass Index, Time on Dialysis, and Hyperparathyroidism. Advances in Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-492866
American Medical Association (AMA)
Madeira, Miguel& Zen, Mário Sérgio& Lacativa, Paulo Gustavo Sampaio& Torres, Carolina Hammes& Lázaro, Ana Paula Pires& Gonçalves, Renato Torres…[et al.]. Decreased Bone Mineral Density in Patients Submitted to Kidney Transplantation Is Related to Age, Body Mass Index, Time on Dialysis, and Hyperparathyroidism. Advances in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-492866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492866