An Update in the Use of Antibodies to Treat Glioblastoma Multiforme
Joint Authors
Rangel-López, Edgar
Hernández-Pedro, Norma Y.
Sotelo, Julio
Pineda, Benjamín
Vargas Félix, Gustavo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Glioblastoma is a deadly brain disease and modest improvement in survival has been made.
At initial diagnosis, treatment consists of maximum safe surgical resection, followed by temozolomide and chemoirradiation or adjuvant temozolomide alone.
However, these treatments do not improve the prognosis and survival of patients.
New treatment strategies are being sought according to the biology of tumors.
The epidermal growth factor receptor has been considered as the hallmark in glioma tumors; thereby, some antibodies have been designed to bind to this receptor and block the downstream signaling pathways.
Also, it is known that vascularization plays an important role in supplying new vessels to the tumor; therefore, new therapy has been guided to inhibit angiogenic growth factors in order to limit tumor growth.
An innovative strategy in the treatment of glial tumors is the use of toxins produced by bacteria, which may be coupled to specific carrier-ligands and used for tumoral targeting.
These carrier-ligands provide tumor-selective properties by the recognition of a cell-surface receptor on the tumor cells and promote their binding of the toxin-carrier complex prior to entry into the cell.
Here, we reviewed some strategies to improve the management and treatment of glioblastoma and focused on the use of antibodies.
American Psychological Association (APA)
Hernández-Pedro, Norma Y.& Rangel-López, Edgar& Vargas Félix, Gustavo& Pineda, Benjamín& Sotelo, Julio. 2013. An Update in the Use of Antibodies to Treat Glioblastoma Multiforme. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492939
Modern Language Association (MLA)
Hernández-Pedro, Norma Y.…[et al.]. An Update in the Use of Antibodies to Treat Glioblastoma Multiforme. Autoimmune Diseases No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-492939
American Medical Association (AMA)
Hernández-Pedro, Norma Y.& Rangel-López, Edgar& Vargas Félix, Gustavo& Pineda, Benjamín& Sotelo, Julio. An Update in the Use of Antibodies to Treat Glioblastoma Multiforme. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-492939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492939