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The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
Joint Authors
Barcia, Carlos
Guillemin, Gilles J.
Zinger, Anna
Herrero, María Trinidad
Source
International Journal of Inorganic Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a common neurodegenerative disorder characterised by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms.
Activated microglia themselves release a large number of inflammatory mediators thus perpetuating neuroinflammation and neurotoxicity.
The Kynurenine pathway (KP), the main catabolic pathway for tryptophan, is one of the major regulators of the immune response and may also be implicated in the inflammatory response in parkinsonism.
The KP generates several neuroactive compounds and therefore has either a neurotoxic or neuroprotective effect.
Several of these molecules produced by microglia can activate the N-methyl-D-aspartate (NMDA) receptor-signalling pathway, leading to an excitotoxic response.
Previous studies have shown that NMDA antagonists can ease symptoms and exert a neuroprotective effect in PD both in vivo and in vitro.
There are to date several lines of evidence linking some of the KP intermediates and the neuropathogenesis of PD.
Moreover, it is likely that pharmacological modulation of the KP will represent a new therapeutic strategy for PD.
American Psychological Association (APA)
Zinger, Anna& Barcia, Carlos& Herrero, María Trinidad& Guillemin, Gilles J.. 2011. The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease. International Journal of Inorganic Chemistry،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492941
Modern Language Association (MLA)
Zinger, Anna…[et al.]. The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease. International Journal of Inorganic Chemistry No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-492941
American Medical Association (AMA)
Zinger, Anna& Barcia, Carlos& Herrero, María Trinidad& Guillemin, Gilles J.. The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease. International Journal of Inorganic Chemistry. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-492941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492941