Mitochondrial Dysfunction in Parkinson's Disease
Joint Authors
Morris, C. M.
Keane, P. C.
Kurzawa, M.
Blain, P. G.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Parkinson's disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial dysfunction and inhibition of the electron transport chain.
This inhibition leads to the generation of reactive oxygen species and depletion of cellular energy levels, which can consequently cause cellular damage and death mediated by oxidative stress and excitotoxicity.
A number of genes that have been shown to have links with inherited forms of PD encode mitochondrial proteins or proteins implicated in mitochondrial dysfunction, supporting the central involvement of mitochondria in PD.
This involvement is corroborated by reports that environmental toxins that inhibit the mitochondrial respiratory chain have been shown to be associated with PD.
This paper aims to illustrate the considerable body of evidence linking mitochondrial dysfunction with neuronal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area.
American Psychological Association (APA)
Keane, P. C.& Kurzawa, M.& Blain, P. G.& Morris, C. M.. 2011. Mitochondrial Dysfunction in Parkinson's Disease. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-492943
Modern Language Association (MLA)
Keane, P. C.…[et al.]. Mitochondrial Dysfunction in Parkinson's Disease. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-492943
American Medical Association (AMA)
Keane, P. C.& Kurzawa, M.& Blain, P. G.& Morris, C. M.. Mitochondrial Dysfunction in Parkinson's Disease. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-492943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492943